day-pay-eez-MON[depɛizmɑ̃]
Pronunciation: Speaker: LoquaxFR Recorder: LoquaxFR · CC BY-SA 4.0 · Wikimedia Commonsthe pleasantly strange feeling of being far from everything familiar
Closest in English: disorientation, displacement, estrangement. None of them covers it.
The French mean it kindly: being lifted out of your own country and set down where the rules are different is the whole point of going — travel firms promise dépaysement the way ours promise sunshine. English only offers disorientation, which sounds like something a doctor should see to.
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The most common guesses for the translation were 'homesick' and 'homesickness'. Close, but not it.